Bio-Targeted Small Molecules Conjugated Particles

Some small molecules can act as novel targeted therapy drugs. Combined with nano technology, ¡°smart¡± drugs which actively target tumors through the interaction of phenotype-specific ligands that are conjugated to the delivery vector can bind with the corresponding receptors on the tumor cells. Additionally, binding to certain receptors may help trigger internalization and potentially help avoid any drug resistance mechanisms that have arisen.

BOT Bioparticles offers custom small molecules conjugated nanoparticles synthesis services. Our long-year synthesis experience makes our particles with uniform size, shape and proper density of conjugation.

Principle of Targeting via Small Molecules

The principle of targeting via small molecules is to target the molecular biology basis of tumorigenesis, usually to regulate the activity of protein targets. The protein targets mainly include enzymes and receptors. These small molecules can be divided into receptor agonists and receptor antagonists while acting on the receptor. Small molecules that act as inhibitors of enzymes reduce their catalytic activity by binding to them.

Some Examples of Bio-Targeted Small Molecules

These small molecules can bind with the highly expressed targets on the surface of cancer cells for active targeting in drug delivery.

1. Folic acid (folate). Cancer and embryonic cells preferentially use the folic acid receptors (FR) that have high affinity for folic acid to absorb folate via receptor-mediated endocytosis, which helps folate become an attractive targeted ligand for active targeting.

2. Glucose transporter targeting agent glufosfamide. Cancer cells highly rely on glucose and glycolysis for survival and express glucose transporters.

Properties of Bio-Targeted Small Molecules Conjugated Particles

1. Active targeting via bio-targeted small molecules.

2. Easy to be internalized with the help of targeted receptors.

3. Reducing the drug resistance.

4. Enhanced permeability and retention effect.

Applications of Bio-Targeted Small Molecules Conjugated Particles

1. Multi-functional particles for chemotherapy drug delivery.

2. Synergy with other therapies like magnetic hyperthermia.

3. Biological imaging.

4. Biosensing

What Does Our Custom Service Provide?

1. Synthesis of basic particles.

2. Functionalization and conjugation of custom small molecules for targeting.

3. Basic characterization.

What Will We Ask You for Starting the Project?

1. Application.

2. Requirement for particles, including diameter, component, etc.

3. Functionalization (type, density, spacer arm, etc.).

4. Desired bio-targeted small molecule.

5. Quantity.

6. Format.

7. QC materials requirement.

Please contact us by info@bot-bioscience.com to discuss your demands, ask for a quote or, request a proposal for our bio-targeted small molecules conjugated particles custom services.